The study
looked at the effect of restricting sugar on metabolic syndrome, a
cluster of conditions that increase the risk of heart disease, stroke
and Type 2 diabetes.
Metabolic
syndrome can include high blood pressure, high blood glucose levels,
excess body fat around the waist and abnormal cholesterol levels.
The
study involved 43 children aged nine to 18 who were asked to visit the
University of California San Francisco Benioff Children's Hospital.
All the
children had a Latino or African-American background because of their
higher risk for certain conditions associated with metabolic syndrome,
such as high blood pressure and high blood glucose levels.
The children were all obese and had at least one other chronic disorder, such as high blood pressure.
Over a period of nine days, the children followed a meal plan that included all snacks and drinks, but restricted sugar intake.
Added sugar was banned but fruit was allowed.
The
diet overall had the same fat, protein, carbohydrate, and calorie
levels as their previous diets at home, with the carbohydrate from sugar
replaced by foods such as bagels, cereals and pasta.
Hot dogs, crisps and pizza from local supermarkets all featured in the diet.
Initial fasting blood levels, blood pressure, and glucose tolerance were assessed before the new meals were eaten.
During the study, if the children did lose weight, they were given more of the low sugar foods to keep weight stable.
Overall,
the total dietary sugar in the meal plan was was reduced from 28 per
cent to 10 per cent, and fructose from 12 per cent to 4 per cent of
total calories.
The
results showed that the new meal plan led to dramatic improvements in
health in a short time, with a drop in blood pressure and cholesterol,
and improved liver function.
Fasting
blood glucose levels fell by five points while insulin levels were cut
by a third, researchers from the University of California San Francisco
and Touro University in California said.
Lead
author, Dr Robert Lustig, of the University of California San
Francisco, said: 'This study definitively shows that sugar is
metabolically harmful not because of its calories or its effects on
weight; rather sugar is metabolically harmful because it's sugar.
'This
internally controlled intervention study is a solid indication that
sugar contributes to metabolic syndrome, and is the strongest evidence
to date that the negative effects of sugar are not because of calories
or obesity.'
Dr Jean-Marc
Schwarz, of Touro University and senior author of the paper, added: 'I
have never seen results as striking or significant in our human studies.
'After only nine days of fructose restriction, the results are dramatic and consistent from subject to subject.
'These
findings support the idea that it is essential for parents to evaluate
sugar intake and to be mindful of the health effects of what their
children are consuming.
'When we took the sugar out, the kids started responding to their satiety [fullness] cues.
'They
told us it felt like so much more food, even though they were consuming
the same number of calories as before, just with significantly less
sugar.
'Some said we were overwhelming them with food.'
Dr Lustig added: 'This study demonstrates that a calorie is not a calorie.
'Where those calories come from determines where in the body they go.
'Sugar
calories are the worst, because they turn to fat in the liver, driving
insulin resistance, and driving risk for diabetes, heart, and liver
disease.
'This has enormous implications for the food industry, chronic disease, and health care costs.'
The study was published in the journal Obesity.
But
UK experts greeted the results with caution. Tracy Parker, heart health
dietitian at the British Heart Foundation, said: ‘This study is
interesting, but we need more research to confirm these findings.’
Professor
Naveed Sattar, of the University of Glasgow, said: 'The results are not
convincing to me – this is a very small study, and it has not been
statistically well controlled.' Source
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